PolyPhil vs. PolyPhil Next: which variant for which skin?
Table of Contents
In short: The difference is the hyaluronic acid. PolyPhil™ contains pure polynucleotides (20 mg/ml) and stands for regeneration and skin quality. PolyPhil™ Next combines polynucleotides with hyaluronic acid (10 mg/ml each) — for mature or dehydrated skin that additionally needs moisture. There is also PolyPhil™ Eye, specifically for the delicate eye area. Which variant is suitable depends on whether your skin primarily needs regeneration or regeneration plus moisture.
At alestetics® at Zurich HB: We decide which variant suits your skin after the measurement. PolyPhil™ costs CHF 500 per ampoule here, the 3-session plan CHF 1’200. First, we measure your skin in the free AURA 3D skin analysis.
If you look into PolyPhil™, you will quickly come across three names — and wonder which one is right for you. Here is the difference in plain terms.
All three are based on the same active ingredient
First, the commonality: All PolyPhil™ variants are polynucleotide skin boosters from the Austrian brand Croma-Pharma, manufactured by Mastelli in Italy. The core is always the same – highly pure polynucleotides that stimulate the skin's own repair cells. None of these variants are fillers; none create artificial volume.
The difference lies in what is additionally included and for which zone the formula is intended.
PolyPhil™ — the pure build-up formula
PolyPhil™ contains 20 mg/ml pure polynucleotides, without hyaluronic acid. This is the variant for skin quality and structure: It stimulates collagen and elastin, improves skin density and texture, and is well-suited for thin, sun-damaged skin as well as for support in Acne scars.
It's worthwhile if your skin primarily needs renewal – and your moisture levels are generally fine.
PolyPhil™ Next — Regeneration and moisture
PolyPhil™ Next combines 10mg/ml polynucleotides with 10mg/ml hyaluronic acid. The idea: biostimulation and immediate hydration in one step. The polynucleotides stimulate the cells, while the hyaluronic acid directly provides moisture.
This variant is made for mature or dehydrated skin that needs both building up from within and a moisture boost. Those who feel their skin looks dull and tired in texture at the same time are often well-suited for this.
PolyPhil™ Eye — for the eye area
The skin around the eyes is thinner and more sensitive than on the rest of the face. PolyPhil™ Eye is specially formulated for this area and works with an adjusted concentration. The aim is firmness and hydration for tired, thin eye areas. More on this in the article Hyaluronic acid injections under the eyes.
The comparison at a glance
| PolyPhil™ | PolyPhil™ Next | PolyPhil™ Eye | |
|---|---|---|---|
| Active ingredient | 20 mg/ml Polynukleotide | 10 mg/ml PN + 10 mg/ml HA | 7.5 mg/ml Polynucleotides |
| Focus | Structure, skin quality | Regeneration + Moisture | Firmness of eyelid skin |
| Ideal for | Thin, sun-damaged skin, acne scars | Mature, dehydrated skin | tired, thin eye area |
| Volume | No | No | No |
How we choose the variant
At the alestetics® clinic in Zurich, we choose the formula based on your skin condition, not trends. We apply all three with the Vital Injector 2™ — leaving no wheals or bumps. A close look at hydration, thickness, and treatment area tells us which formula fits.
This view is provided by the free AURA 3D skin analysis. You'll find the prices on the PolyPhil™ Page.
Read on
- PolyPhil™ – The Treatment Page
- Plinest or PolyPhil? The Mastelli connection
- Polynucleotides or hyaluronic acid: which is better for skin quality?
What is the difference between PolyPhil and PolyPhil Next?
Which PolyPhil variant is right for me?
Does PolyPhil contain hyaluronic acid?
Is PolyPhil a filler?
Who manufactures PolyPhil?
Written by
Alexandra Stroganova
Founder of alestetics® · Pre-ageing specialist
Medical cosmetologist · Certificate of competence V-NISSG · Lymph therapist · since 2021
Alexandra founded alestetics® in Zurich in 2021. She works according to the ‘pre-ageing’ philosophy: improving skin quality early on, rather than trying to conceal it later.
Find out more about Alexandra and the team →