PolyPhil™ polynucleotides: rebuilding skin from within

All three are polynucleotide skin boosters from Croma-Pharma — each with a different focus:

• PolyPhil™ — 20 mg/ml polynucleotides. The basic formula for pure biostimulation. Ideal for young to mature skin, with a focus on skin quality, skin density, fine lines and acne scars.
• PolyPhil™ Next — 10 mg/ml polynucleotides + 10 mg/ml hyaluronic acid. The combined formula — biostimulation and hydration in one. Ideal for mature or dehydrated skin.
• PolyPhil™ Eye — specially formulated for the delicate eye area. Firms and hydrates without the risk of fillers, ideal for tired-looking eyes and fine lines around the eyes.

We’ll decide together during your consultation which option is right for you — based on your skin type, your skincare goals and the area to be treated.

A PolyPhil™ treatment costs CHF 500 per ampoule — including a personalised mask, Dermalux™ LED phototherapy and a relaxing head massage.

One ampoule (2 ml) is sufficient to treat either the Eye area, the whole face or Neck and décolletage. If you combine several areas (e.g. face + neck and décolletage), you will need two ampoules — so CHF 1,000.

The 3-session package gives you 3 sessions for CHF 1,200 — matched to a standard 6–8-week build-up course.

The standard protocol at alestetics® is 3 sessions at intervals of 2–3 weeks as a restorative treatment. Initial improvements in hydration and skin texture are often visible within days, whilst the full results, achieved through collagen regeneration, develop over 4–12 weeks.

We therefore recommend a Maintenance: 1–2 sessions per year, depending on your skin goals and in line with your overall treatment plan.

No. "Salmon sperm" is a sensationalist term used on TikTok and social media that is scientifically inaccurate. What is actually used is highly purified polynucleotides made from European freshwater fish (suitable for human consumption).

Mastelli's PN-HPT® technology removes Proteins, contaminants, and biological residues — this leaves behind biocompatible active fragments. What is injected are not biological cells, but pure polynucleotide strands — chemically similar to those that naturally occur in your own skin.

The TikTok term is clickbait. What you get is European GMP quality in line with pharmaceutical standards.

Thanks to PN-HPT® technology, all proteins removed — this increases the risk of allergies significantly reduced. All that remains are pure polynucleotide chains whose chemical structure matches that of the body’s own.

Even so, if you have a known fish allergy, we assess suitability individually during your consultation. For severe fish allergies, we recommend alternatives such as NCTF® 135 HA, which contains no animal-derived ingredients.

Thanks to the vacuum control of the Vital Injector 2™, the treatment is nearly painless. Instead of single pricks, 5 needles enter simultaneously at a precise depth — you feel light pressure, not sharp stings.

Most female clients find the session easy to cope with, Many even describe it as relaxing due to the even vibration.

Both are active ingredient treatments administered via the Vital Injector 2™, but with different active ingredient profiles:

• PolyPhil™: Focus on Polynucleotides — Fibroblast stimulation, collagen and elastin production, antioxidant cell protection, tissue repair. Ideal for restorative treatment, acne scars and thin, sun-damaged skin.
• NCTF® 135 HA: Focus on 60 essential active ingredients — Hyaluronic acid, 12 vitamins, 24 amino acids, co-enzymes, minerals, glutathione. Ideal for skin quality, radiance and holistic nourishment of the skin matrix.

We use the AURA 3D skin analysis to determine which treatment is best suited to you. We often alternate between the two within a treatment plan — but never in the same session (with a two-week interval).

Yes — and these are very powerful combinations. The strategy varies depending on the treatment:

• Vivace® RF Microneedling — can be done during the same session: After Vivace®, the microchannels remain open for 4–6 hours — PolyPhil™ can be applied directly afterwards to the open skin matrix. Perfect conditions for the deep penetration of polynucleotides.
• Volnewmer® RF — spaced apart: We use PolyPhil™ to prepare the skin before Volnewmer® or consolidate results afterwards, never in the same session (2 weeks apart).
• Stellar M22™ IPL — the following treatments can be carried out in the same session: Following IPL treatment, it acts as a regenerative layer — soothing the skin and rebuilding the skin matrix.

When using peels such as BioRePeel® or PRX-T33® in the same session, the ideal combination is: the peel first, followed by PolyPhil™.

PolyPhil™ cannot be used in the following cases:

• Active skin infections or herpes in the treatment area
• Severe fish allergy (to be assessed on a case-by-case basis)
• Autoimmune diseases or active immunotherapy
• Severe bleeding disorder or taking blood-thinning medication
• Pregnancy and breastfeeding
• Anyone under the age of 18

If you have any specific medical conditions or are taking medication, we will discuss your suitability on a case-by-case basis during your consultation.