Hormone skin: Not your skincare – your hormones are changing the skin.

Because a single hormone plays a major role: oestrogen. It regulates how much collagen the skin produces, how much water it retains, and how robust its barrier is. When oestrogen levels drop, the very foundation on which the skin has functioned for decades changes. Studies show that women can lose up to 30% of their skin’s collagen in the first five years after the menopause — and this loss follows hormonal age, not calendar age. That is why it often happens faster than one might expect.

Source: Brincat MP et al., Estrogens and the skin. Climacteric. 2005;8(2):110–123.

Several things at once. As oestrogen levels decline, collagen and skin density decrease, and the skin becomes thinner and less firm. It retains less moisture and becomes drier, the skin barrier becomes more permeable and sensitive, and wound healing slows down. A review article describes precisely this pattern — dryness, atrophy, fine lines and poorer healing — as a consequence of oestrogen deficiency. This is not a question of skincare, but a structural issue.

Source: Rzepecki AK et al., Estrogen-deficient skin: The role of topical therapy. International Journal of Women's Dermatology. 2019;5(2):85–90.

Little is certain. Peptides are signalling proteins, and injectable variants such as GHK-Cu or BPC-157 are currently being heavily promoted. However, none of them are approved for skin rejuvenation — even the FDA has not authorised them, but has classified many due to safety concerns: potential immune reactions, contamination and a lack of data on humans. A large proportion circulates as laboratory chemicals of unknown origin and quality. We do not inject anything whose safety and dosage have not been proven.

This is because the active ingredients need to reach the place where they are intended to work — the dermis. Polynucleotides (PDRN/PN) are large molecules and can barely penetrate the intact skin barrier; whether an active ingredient is best applied topically or by injection depends directly on its molecular size. Accordingly, visible results in studies come from injections, not from serums. That is why PolyPhil™ is administered as an injection — and as an approved, CE-certified medical device, not as a grey-market substance.

Source: From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications. Review, 2025.

Growing, but to be honest, still in its infancy. A systematic review from 2025 summarises the studies on polynucleotides in aesthetic medicine and notes improvements in skin elasticity, hydration and texture with good tolerability — but at the same time points to small sample sizes and varying study quality. We do not market this as a miracle cure, but as a well-founded building block that has proven its worth in practice.

Source: Lampridou E et al., The Effectiveness of Polynucleotides in Aesthetic Medicine: A Systematic Review. Journal of Cosmetic Dermatology. 2025.

Skin helps to prove it: An estrogen replacement therapy directly targets the cause (as decided by your doctor), and can restore collagen and skin density. But that is a medical decision that weighs all your health factors and is in the hands of your doctor — not a skin clinic. We do not prescribe hormones. We focus on collagen building, skin quality and hydration, and this can be well combined with medically supervised hormone therapy.

Source: Brincat MP et al., Estrogens and the skin. Climacteric. 2005;8(2):110–123.

Yes, that’s typical. When oestrogen levels drop, the balance shifts in favour of androgens — and these relatively stronger androgens can trigger breakouts on the chin and jawline, often for the first time since adolescence. The cause is different from that of teenage acne, which is why a different approach is needed. Read more at Acne & blemished skin →.

More than you might think — and doubly beneficial at this stage of life. In one study, strength training in women improved skin elasticity and the structure of the dermis, increased skin thickness and reduced inflammatory markers in the blood. Together with bone and muscle protection, this is a strong argument, particularly around the time of the menopause. It is no substitute for treatment, but it does play a part in determining how effective it is.

Source: Nishikori S et al., Resistance training rejuvenates ageing skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices. Scientific Protocols. 2023;13:10214.

It depends on the plan — hormonal skin is treated with a combination of structural and quality treatments plus maintenance, not with a single appointment. You can find an overview of the treatments on our Prices page →. Not ready for an on-site analysis yet? Our Skin Quiz → gives you a quick overview in five minutes.